Staff Profile
Professorial Fellow
David Palmer
MSc (Toronto) PhD (Massey)
Contact Details
Faculty of Agriculture and Life Sciences
| Location | Hilgendorf 441 |
| Phone | 8136 |
| Extension | 64 3 325 2811 |
| David N. Palmer |
Currently Teaching
Supervision of Honours and Graduate students in aspects of Batten disease. BICH 326, BICH 601, BICH 602.
Academic and Professional Background
Member of:
- New Zealand Society of Biochemistry and Molecular Biology (President)
- Lysosomal Diseases New Zealand Trust (Trustee)
- New Zealand Organisation for Rare Diseases
- Australian Batten Disease Support and Research Association
- Neurological Foundation of New Zealand.
Current Research and Publications
Animal models for human disease, particularly Batten disease.
- Related genetics, neuroscience, biochemistry, cell biology, neuropathology and cell culture.
Understanding the genetic, biochemical and cell biology lesions in the group of inherited fatal neurodegenerative diseases of children known as Batten disease (neuronal ceroid-lipofuscinoses (NCLS)). Current efforts are concentrated on defining the pathogenesis and using affected sheep as a model for possible treatments.
This work involves a number of collaborations with workers in New Zealand, Australia, Europe, and the USA.
Selected Publications
Over 70 refereed publications. Over 1600 citations.
Palmer, D.N. Batten disease and rare inherited diseases. The Cook Islands Annual Health Conference, 9-11 July, Cook Islands, 2007.
Palmer, D.N., Kay, G.W., Frugier, T.J., Hughes, S.M., Cooper, J.D. Studies towards anti-inflammatory and gene therapy in ovine Batten disease. 11th International Congress on Neuronal Ceroid Lipofuscinosis (Batten disease), 14-17 July, Rochester, New York. O52, 2007.
Kay, G W, Oswald, M J & Palmer, D N. The development and characterisation of complex ovine neuron cultures from fresh and frozen foetal neurons. Journal of Neuroscience Methods 155: 98-108, 2006.
Kay, G W, Palmer, D N, Rezaie, P and Cooper, J D. Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis (CLN6). Brain Pathology 16: 110-116, 2006.
Oswald, M J, Palmer, D N, Kay, G W, Shemilt, S J, Rezaie, P & Cooper, J D. Glial activation spreads from specific cerebral foci and precedes neurodegeneration in presymptomatic ovine neuronal ceroid lipofuscinosis (CLN6). Neurobiology of Disease 20: 49-63, 2005.
Chen, R, Fearnley, I M, Palmer, D N & Walker, J E. Lysine 43 is trimethylated in subunit c from bovine mitochondrial ATP synthase and in storage bodies associated with Batten disease. The Journal of Biological Chemistry 279: (21): 21883-21887, 2004.
Heine, C, Koch, B, Storch, S, Kohlschutter, A, Palmer, D N & Braulke, T. Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A. Journal of Biological Chemistry 279: (21): 22347-22352, 2004.
Heine, C, Tyynel , J, Cooper, J D, Palmer, D N, Elleder, M, Kohlschutter, A & Braulke, T. Enhanced expression of manganese dependent superoxide dismutase in human and sheep CLN6 tissues. Biochemical Journal 376: 369-376, 2003.
Every effort is made to ensure the information contained herein is correct at the time of printing, but the content may be subject to change. Lincoln University reserves the right to make changes, amendments or deletions - including withdrawal of courses, should circumstances change. Lincoln University does not assume and hereby disclaims any express or implied liability whatsoever to any party for any loss or damage caused by errors or omissions, whether these errors or omissions result from negligence, accident or any other cause.
Site Navigation Links:Jump to main page content.